Here is the program BiokmodWeb site developed in Mathematica, webMathematica and Java. It runs on line, you do not need other think that your browser. It contains some features of the Mathematica Tool BIOKMOD to be applied in pharmacokinetic, internal dosimetry, and nuclear medicine.

You can make directly in this website:

· To build compartmental models (constant and variable coefficients can be used) in a very easy way generating automatically the system of differential equations and their solutions, graphic representation and US (disintegrations). A specific function for multiinputs (single and constant inputs) is included.

· To solve ICRP Models for practically all isotopes (including some specific options for Lung and Respiratory Tract) obtaining the Intake Retention Fractions (IRF), their analytical expressions (intake retention functions), the compartmental contents and the graphic representations. Acute, constant -chronic, continuous (variable in the time) and multi-inputs,  even random, intakes can be used. You can accepted the default parameters or introduce specific values.  They can be used to bioassay evaluations and for research and education purposes.

· To compute the committed doses for some isotopes using non standard values. It can be expanded for many isotopes computing the accumulated disintegrations (with the function Desintegrations) and using the SEE factor supplied by other free programs as DCAL .

· An optimal design function is included. It can be used to establish the best moment where experimental sample or bioassay should be taken.

· Fitting functions for non linear fitting. They are applied some optimization developed by the authors an other algorithms included  in Mathematica,

· A function for evaluating uncertainties analytically.

The BiokmodWeb is considerably expanded by  BIOKMOD (Mathematica is required). It can be downloaded pushing here, including detailed information about the program.

Some papers have been published where BIOKMOD has been used (below are referenced some of them). For additional information visit the author website: http://web.usal.es/guillermo.  If you have comments, bug reports or suggestions sends an e-mail to author Guillemo Sánchez

Sánchez G; “Fitting bioassay data and performing uncertainty analysis with BIOKMOD”  Health Physics. 92(1) :64-72. 2007. ISSN/ISBN: 0017-9078  (download)

Sánchez G;. Rodríguez-Díaz J. M. Optimal design and mathematical model applied to establish bioassay programs”: Radiation Protection Dosimetry. doi:10.1093/rpd/ncl499. 2007. ISSN/ISBN: ISSN 1742-3406

Lopez-Fidalgo J Rodriıguez-Díaz J.M.,Sánchez G; G., Santos-Martín M.T. Optimal designs for compartmental models with correlated observations” 

Journal of Applied Statistic. 32, 2006  ISSN/ISBN: 0266-4763

Sánchez G; Biokmod: A Mathematica toolbox for modeling Biokinetic Systems”. Mathematica in Education and Research: 10 (2) 2005. ISSN/ISBN:  1096-3324 (download)

Sánchez G; Lopez-Fidalgo J “Mathematical Techniques for Solving Analytically Large Compartmental Systems” Health Physics..: 85 (2): 2003. ISSN/ISBN: 0017-9078 

Lopez-Fidalgo J; Sánchez G; Statistical Criteria to Establish Bioassay Programs. Health Physics.. 89 (4). 2005. ISSN/ISBN: 0017-9078.